Table 2 Discovery cohort demographics by SSRI and depression group status.

From: Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy

Depression group

SSRI-exposed, maternally-depressed

SSRI-exposed, not maternally depressed

SSRI non-exposed, maternally-depressed

SSRI non-exposed, not maternally-depressed

SSRI exposed vs non-exposed p value† (maternally-depressed)

SSRI exposed vs non-exposed p value† (not maternally-depressed)

Depressed

Not depressed

Depressed

Not depressed

Depressed vs. depressed

Not depressed vs. not depressed

n

14

6

20

24

  

Maternal Hamilton Depression Score (mean (SD))

26 weeks

13.4 (3.9)

4.5 (2.4)

9.7 (2.6)

4.3 (2.2)

0.003*

0.841

36 weeks

12.8 (2.8)

5.6 (2.6)

11.0 (2.2)

5.8 (2.7)

0.045*

0.869

Mean

13.0 (2.9)

5.2 (1.8)

10.5 (2.2)

5.0 (2.1)

0.009*

0.877

Length SSRI exposure (days, mean (SD))

266.93 (19.28)

258.33 (48.65)

–

–

–

–

Type of SSRI exposure (n (%))⁋

Citalopram

5 (35.7)

2 (33.3)

–

–

–

–

Escitalopram

5 (35.7)

2 (33.3)

–

–

  

Fluoxetine

0 (0.0)

1 (16.7)

–

–

  

Paroxetine

1 (7.1)

0 (0.0)

–

–

  

Sertraline

3 (21.4)

1 (16.7)

–

–

  

Delivery type (n vaginal (%))

5 (35.7)

5 (83.3)

11 (55.0)

18 (75.0)

0.281

0.99

Gestational age at birth (weeks, mean (SD))

39.1 (1.4)

39.7 (1.4)

39.6 (1.3)

39.5 (1.4)

0.447

0.697

Gestational diabetes (n, mean (SD))

0 (0)

0 (0)

0 (0)

0 (0)

–

–

Infant sex (n male (%))

6 (42.9%)

2 (33.3%)

11 (55.0%)

14 (58.3%)

0.727

0.522

Infant birthweight Z-score (mean (SD))

− 0.01 (1.06)

0.00 (0.94)

− 0.02 (0.62)

− 0.05 (0.82)

0.989

0.906

PlaNET ancestry§ (mean (SD))

Coordinate 1

0.00 (0.00)

0.00 (0.00)

0.01 (0.02)

0.00 (0.00)

0.292

0.665

Coordinate 2

0.07 (0.25)

0.01 (0.01)

0.14 (0.32)

0.12 (0.31)

0.488

0.370

Coordinate 3

0.93 (0.25)

0.99 (0.01)

0.85 (0.32)

0.87 (0.31)

0.460

0.369

  1. Maternal depression was categorized using mean maternal Hamilton Depression score, \(\le\) 8 was categorized as not depressed, > 8 as depressed, this is reflected in the “Depression Group” row. SSRI refers to selective-serotonin reuptake inhibitor treatment during pregnancy. Birthweight Z scores were calculated using gestational-age and sex-adjusted birthweight curves45.
  2. †p values are from chi-squared tests for categorical variables and t-tests for continuous variables, * indicates < 0.05, ** indicates < 0.005.
  3. ⁋p = 0.59 (chi-squared test) for proportion of SSRI types utilized by SSRI-exposed, maternally-depressed participants versus SSRI-exposed, not maternally-depressed participants.
  4. §The PlaNET algorithm outputs DNAme-based ancestry probability values ranging from 0–1, which sum to 1 for each sample. Coordinate 1 is associated with probability of African ancestry, coordinate 2 with East Asian ancestry, and coordinate 3 with European ancestry46.
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