Figure 1
From: Pre-exposure cognitive performance variability is associated with severity of respiratory infection
Pre-exposure cognitive performance variability (CPV) score is strongly associated with post-exposure outcome. (a) Challenge study layout showing baseline and post-inoculation biomarker sampling times for a study participant. (b) Definition of 18 NCPT variables measuring participant performance on 4 different tests: Digital Symbol Coding (DigSym), Go/No-Go (Reaction), Trail Making (Trail) and Attention Cuing (Posner). (c) Heatmap of univariate CPV scores for each study participant. participants are ordered from left to right in terms of decreasing amounts of post-exposure shedding. NCPT measures are ordered from top to bottom in terms of decreasing CPV max value over the participants. (d) Scatterplot of CPV and outcome for the 18 participants. Shedding (log\(_{10}\) TCID\(_{50}\)/ml) and symptom (modified Jackson score) are aggregated over the full post-exposure period of the study. (e) Boxplots of the resampled univariate CPV scores, computed by successively leaving out a session, over the 18 NCPT variables in Fig. 1b for two of the lowest shedding (top row) and two of the highest shedding (bottom row) challenge study participants. Solid blue curve indicates the CPV scores shown in heatmap (c).
