Figure 4 | Scientific Reports

Figure 4

From: Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer’s disease

Figure 4

Behavioral results for the open field, novel object recognition (NOR), novel object location (NOL) tasks, and the Y-maze. (a) A schematic of the open field. (b) Distance travelled was comparable between groups in adulthood. (c) Time spent in the outer zone of the box was comparable between groups in adulthood. (d) A schematic of the NOR task. (e) Learning of NOR led to significant increase in discrimination index from training to testing (p < 0.0001), while the genotype effect, aging effect, and interactions were not significant. (f) A schematic of the NOL task. (g) Learning of NOL recognition led to significant increase in discrimination index from training to testing (p < 0.0001), while the genotype effect, aging effect, and interactions were not significant. (h) A schematic of the Y-maze. (i) Spontaneous alternation in the Y-maze was not affected by genotype. It was significantly above chance in both groups and at both ages (all p < 0.001). All data presented as mean ± SEM. ***p < 0.001.

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