Figure 5

Immunohistochemistry (6E10) for showing amyloid burden. (a) Representative hippocampal images of a WT mouse (top) and a AppNL-G-F/NL-G-F mouse (bottom). (b) The percentage of 6E10-positive hippocampal area was significantly above 0 but below what was reported (dashed line inferred from Saito et al.3). (c) The number of plaques in the hippocampus was significantly above 0. Data is presented as mean ± SEM. *p < 0.05, **p < 0.01.