Figure 5

Involvement of peptidyl-prolyl cis-trans isomerase FKBP4 isoform X2 (FKBP4), steroid hormone receptor ERR1 (ESRRA), immunoglobulin superfamily member 10 (IGSF10) and ATP-binding cassette subfamily B member 5 (ABCB5) in networks of protein–chemical agent interactions based on KEGG pathways. Red circles: FKBP4, ESRRA, IGSF10 and ABCB5. Abbreviations: AHSA1, activator of heat shock 90 kDa protein ATPase homolog 1 (also known as AHA1); AKT1, v-akt murine thymoma viral oncogene homolog 1; CDC37, cell division cycle 37 homolog; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); ESR1, estrogen receptor 1 (nuclear hormone receptor); ESRRG, estrogen-related receptor gamma; GLMN, glomulin (FKBP associated protein); HSP90AA1, heat shock protein 90 kDa alpha (cytosolic), class A member 1; HSP90AB1, heat shock protein 90 kDa alpha (cytosolic), class B member 1; NCOA3, nuclear receptor coactivator 3; PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PPP5C, protein phosphatase 5, catalytic subunit; PTGES3, prostaglandin E synthase 3 (cytosolic); SRC, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; STIP1, stress-induced-phosphoprotein 1; SUGT1, suppressor of G2 allele of SKP1 (also known as SGT1). Chemical agents: estrogen, rapamycin, tacrolimus and XCT790.