Figure 3

Effect of the seven 2,3-dihydroquinazolin-4(1H)-one analogues (C1–C7) on the migration of PC3 and DU145 prostate cancer cell line. Wound healing assay presented as % of wound closure after 24 h, 48 h and 72 h treatment compared to control untreated cells in (A) PC3 and (B) DU145 cell lines. Effect of C2 and C5 on wound in PC3 (C) and DU145 (D) cell lines well at time 0 h, 24 h 48 h and 72 h. Data in A and B are shown as mean ± SD of triplicates compared with the untreated control. One-way ANOVA analysis using Tukey’s post hoc test was used to indicate significance. ^* P-value ≤ 0.05, ^**P-value ≤ 0.01, ^***P-value ≤ 0.001, ^****P-value ≤ 0.0001 compared to control.