Figure 8 | Scientific Reports

Figure 8

From: Molecular and metabolic alterations of 2,3-dihydroquinazolin-4(1H)-one derivatives in prostate cancer cell lines

Figure 8

A scheme representation of the different intermediates affected pathways in DU145 cells after treatment with C5 and C6. PPP: pentose phosphate pathway, GSH: glutathione, GSSG: oxidized glutathione, DHT: dihydrotestosterone, G-6-P: Glucose 6-phosphate, 6-P-G-one: 6-phosphogluconate, r-5-P, SAM: S-Adenosyl methionine, 5-HTOL: 5-hydroxytryptophan, PhCho: phosphatidylcholine, LPCho: lysophosphatidylcholine, and GPCho: Glycerophosphocholine. Red arrows indicate upregulation, while blue arrows indicate down regulation.**Significant in DU145 cells treated with C5 only, *Significant in DU145 cells treated with C6 only, and underlined metabolite is significant in both C5 and C6.

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