Table 2 Univariate and multivariate regression analysis of metastasis biomarkers in the study cohort.

Variables	Metastasis
Variables	HR	95% CI		P
Univariate
Size ≥ 60 mm	0.841	0.391	− 1.806	0.657
N stage (N2 vs N1 vs N0)	2.563	1.545	− 4.251	< 0.001
Differentiation (PD vs MD vs WD)	0.942	0.275	− 3.226	0.924
LVI	2.971	1.442	− 6.122	0.003
PNI	2.199	1.087	− 4.450	0.028
Tumor budding	0.481	0.216	− 1.072	0.073
NEK9	2.476	1.520	− 4.033	< 0.001
EG5	1.139	0.881	− 1.472	0.320
Acetyl-α-tubulin	1.293	0.866	− 1.932	0.209
E-cadherin	0.757	0.455	− 1.261	0.285
Vimentin	0.440	0.088	− 2.210	0.319
Claudin-1	0.561	0.336	− 0.937	0.027
ꞵ-Catenin	1.885	0.191	− 18.633	0.588
Multivariate
Size ≥ 60 mm	1.237	0.460	− 3.327	0.673
N stage	2.496	1.284	− 4.852	0.007
LVI	2.090	0.761	− 5.739	0.153
PNI	1.496	0.562	− 3.983	0.420
NEK9	3.365	1.786	− 6.340	< 0.001
EG5	0.917	0.648	− 1.298	0.625
Acetyl-α-tubulin	1.397	0.823	− 2.372	0.216
E-cadherin	0.537	0.266	− 1.087	0.084
Vimentin	0.335	0.05	− 1.912	0.218
Claudin-1	0.554	0.286	− 1.073	0.080
ꞵ-Catenin	2.156	0.110	− 42.298	0.613

WD well differentiated, MD moderately differentiated, PD poorly differentiated, LVI lymphovascular invasion, PNI perineural invasion.

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