Figure 4
From: Potential benefits of using radioactive ion beams for range margin reduction in carbon ion therapy
Normal tissue complication probability estimations for ACC patients. (a) NTCP (endpoint optic neuropathy) estimated for the right and left optic nerves for each patient using the Lyman-Kutcher-Burman model with parameters from51 for 12C and 11C treatment plans. Single points correspond to the patient-specific median NTCP values. Stars represent the result of the Wilcoxon Signed-Rank test (P = 0.00006 for the right nerve and P = 0.0003 for the left nerve) for both plots. (b) Relative risks (RR) representing the ratio of 11C versus 12C NTCP values for individual patients for the right (dashed bar) and left (solid color bars) optic nerves. RR < 1 means that the 11C plan is beneficial compared to 12C plan in terms of optic system toxicity. Top: nominal scenarios, bottom: worst-case scenarios.
