Table 1 Demographic and clinical characteristics of the studied groups.

From: Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism

Parameters

Groups

P value

Healthy controls (n = 95)

Hypothyroid patients

Subclinical (n = 110)

Clinical (n = 100)

Age (years)

36.63 ± 8.76

37.64 ± 7.74

39.15 ± 8.98

0.113

Gender

   

0.67

Female, n (%)

87 (91.58%)

104 (94.55%)

92 (92%)

 

Male, n (%)

8 (8.42%)

6 (5.45%)

8 (8%)

 

BMI (kg/m2)

22.57 ± 2.94

29.7 ± 6.22#

30.51 ± 4.96#

 < 0.0001

TSH (mIU/L)

1.57 (1.16–2.02)

7.68(6.07–12.2)#

26.35 (14.25–75.38)#$

 < 0.0001

Free T4 (ng/dL)

1.26 ± 0.12

1.33 ± 0.5

0.61 ± 0.22#$

 < 0.0001

Free T3 (pg/mL)

3 ± 0.53

3.11 ± 0.59

2.01 ± 0.69#$

 < 0.0001

Thyroid volume (mL)

2.69 (2.14–3.94)

4.35 (2.64–6.65)#

7.1 (4.76–8.52)#$

 < 0.0001

Lipid profile

Total cholesterol (mg/dL)

159.4 ± 28.72

181.8 ± 45.6#

196.7 ± 47.80#

 < 0.0001

LDL-cholesterol (mg/dL)

91.81 ± 28.02

111.1 ± 40.05#

125.3 ± 44.94#

 < 0.0001

HDL-cholesterol (mg/dL)

55.17 ± 14.41

46.9 ± 12.59#

43.81 ± 9.71#

 < 0.0001

Triglycerides (mg/dL)

64 (47–96)

105 (60.8–156.5)#

132 (93.25–172.3)#$

 < 0.0001

Sugar profile

Fasting plasma glucose (mg/dL)

71.8 ± 3.9

80.71 ± 9.22#

85.69 ± 8.87#$

 < 0.0001

2HPP blood glucose (mg/dL)

100 ± 6.6

116 ± 15.18#

126.4 ± 10.87#$

 < 0.0001

HbA1c (%)

4.69 ± 0.27

4.98 ± 0.3#

5.37 ± 0.36#$

 < 0.0001

Fasting plasma insulin (IU/L)

5.2 (4.3–11.5)

8.3 (4.8–14.03)#

9.35 (6.8–16.58)#$

 < 0.0001

  1. Data are presented as mean ± SD, median (25–75% percentiles) or number (percentage). BMI: body mass index, HbAIc: glycated hemoglobin, 2HPP: 2-h postprandial, TSH: thyroid stimulating hormone. #Statistical significance from healthy controls, $Statistical significance from subclinical hypothyroid patients. P values of ANOVA or Kruskal Wallis tests (when appropriate) across the three groups are presented. Bold means statistical significance between groups, P < 0.05.
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