Table 2 Basic information of studied single nucleotide polymorphisms and odds ratio estimates for subclinical and clinical hypothyroidism.

From: Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism

gene name

SNP ID (allele)

Global MAF* (T allele)

MAF (healthy controls)

MAF (subclinical hypothyroidism)

ORa (95% CI)

Pa value

MAF (clinical hypothyroidism)

ORa (95% CI)

Pa value

LncRNA-PAX8-AS1

rs4848320 (C/T)

T = 0.21

T = 0.26

T = 0.31

1.28 (0.82–1.99)

0.27

T = 0.42

2.01 (1.30–3.09)

0.0015

rs1110839 (G/T)

T = 0.48

T = 0.3

T = 0.31

1.03 (0.68–1.58)

0.88

T = 0.495

2.22 (1.46–3.38)

 < 0.0001

LAIR-2

rs2287828 (C/T)

T = 0.11

T = 0.08

T = 0.36

6.64 (3.65–12.06)

 < 0.0001

T = 0.43

8.50 (4.66–15.49)

 < 0.0001

  1. MAF minor allele frequency. *According to Ensembl release 102—November 2020. OR odds ratio, CI confidence interval. aAdjusted for age and sex in a logistic regression model using SNPstats online software. P values in bold means statistical significance from healthy controls (P < 0.05).
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