Figure 3 | Scientific Reports

Figure 3

From: Correspondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data

Figure 3

Geometric interpretation of correspondence analysis: Illustrating associations between genes and cell populations. Biplot of the first two dimensions of CA in the Zhengmix8 dataset. The eight cell populations are colored by type, while genes are labeled and colored in blue. The top twenty genes by weight (furthest from the origin in the first two components) are shown. Six biologically significant genes are highlighted, and ridge plots illustrate their log-expression: GNLY is highly expressed in NK cells, whereas TYROBP is highly expressed in both NK and CD14 monocytes. LYZ and S100A8 are both highly expressed, monocyte-specific genes. Both CD74 and HLA-DRA are highly expressed in B cells, and moderately expressed in monocytes, as shown in the respective ridgeplots.

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