Figure 6

General description of the approach. (A) Moderate stretch injury upgrades neuronal expression of BACE1 and Aβ, downgrades neuronal expression of APP, synaptic abnormalities (e.g., decreased expression of both MAP2 and synaptophysin), and reduced viability. In addition, the injured neurons may secrete Aβ debris to injure the healthy neighborhood neurons. The CD206⁺ microglial cells with normal phagocytic capacity may protect against stretch injury via reducing synaptic abnormalities (I) and phagocytosing the Aβ debris (II). The injured microglia (CD16/32⁺) with reduced phagocytic capacity may injury the healthy neurons via upgrading neuronal expression of BACE1 and Aβ, downgrading neuronal expression of APP and downgrading the phagocytic capacity for removal of Aβ debris, and synaptic abnormalities (B).