Figure 3 | Scientific Reports

Figure 3

From: Transcriptome-wide analysis reveals the coregulation of RNA-binding proteins and alternative splicing genes in the development of atherosclerosis

Figure 3

Correlation analysis of RBPs and RASEs in atherosclerotic plaques in the early disease stage (SAMP_DIT) and advanced disease stages (SAMP_advanced). (A) Venn diagram depicting regulated differentially expressed genes (DEGs) and RNA binding proteins (RBPs), p-value = 1. (B) heatmap showing differentially expressed RBPs with a FPKM of greater than 1 in at least 80% of samples. Cluster analysis based on the expression of differential RBP genes between groups. (C) The 20 most enriched GO terms in RASGs with expression disrupted by RBPs. (D) Deregulation of the AS network by the 10 most enriched RBPs (purple) and RASEs (blue). The 4 enriched GO terms associated with atherosclerotic plaque with RASGs (yellow) with disrupted expression shown in red.

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