Table 2 Comparison of discordant antibiotic resistance phenotypes between ETT-deposited BF and colonization/infection sites for eleven patients.
Patient | Bacterial species | MIC in BF (mg/L) | Resistance phenotype in BF | MIC in colonization site (mg/L) | Discordant phenotype from colonization sites | Most suspected resistance mechanism | Highest resistance in BF |
|---|---|---|---|---|---|---|---|
1 | Stenotrophomonas maltophilia | > 16 | TMP/SMX-resistant | 0,125 | TMP/SMX-susceptible (TBA-BAL) | Acquisition of sul genes | + |
6 | Staphylococcus aureus | 32 (Benzylpenicillin) | Penicillinase | 0,06 | Wild-type (TBA-BAL) | Acquisition of blaZ genes | + |
12 | Escherichia coli | 32 (Piperacillin/tazobactam) | High-level penicillinase | < 4 | Low-level penicillinase (urinalysis) | Acquisition of blaTEM genes | + |
13 | Escherichia coli | 16 (Ampicillin) | Low-level penicillinase | 2 | Wild-type (blood culture) | Hyperproduction of the acquired penicillinase | + |
14 | Stenotrophomonas maltophilia | 24 | Ceftazidime-resistant | 4 | Wild-type (TBA-BAL) | Hyperproduction of the chromosomal β-lactamase (L2) | + |
21 | Staphylococcus haemolyticus | < 0,03 | Rifampin-susceptible | > 2 | Rifampin-resistant (blood culture) | Mutation in rpoB genes | – |
26 | Pseudomonas aeruginosa | 8 | Gentamicin-resistant | 3 | Gentamicin-susceptible (TBA-BAL) | Acquisition of aac genes | + |
27 | Klebsiella aerogenes | 16 (ceftazidime) | High-level cephalosporinase | < 1 | Wild-type (TBA-BAL) | Hyperproduction of the chromosomal cephalosporinase (AmpC) | + |
36 | Staphylococcus aureus | > 4 | Erythromycin-resistant | 1 | Erythromycin-susceptible (TBA-BAL) | Acquisition of erm genes | + |
49 | Raoultella ornithinolytica | 1 (Amoxicillin/clavulanic acid) | Wild-type | 32 | High-level penicillinase (TBA-BAL) | Hyperproduction of the chromosomal penicillinase | – |
57 | Pseudomonas aeruginosa | > 128 | Ceftazidime-resistant | 1 | Wild-type (TBA-BAL) | Hyperproduction of the chromosomal cephalosporinase (AmpC) | + |
