Table 3 Sex differences in regional phosphorus metabolite levels.

Metabolite	Region	Group	Mean	Std. error	95% C.I		P*
ATP/PCr	Frontal	Female	0.410	0.010	0.390	0.429	0.002
	Frontal	Male	0.351	0.010	0.331	0.370
	Fusiform	Female	0.916	0.016	0.883	0.948
	Fusiform	Male	0.880	0.016	0.848	0.912
	Medial temporal	Female	0.242	0.004	0.233	0.250
	Medial temporal	Male	0.231	0.004	0.223	0.239
	PCC	Female	0.366	0.009	0.349	0.384
	PCC	Male	0.344	0.009	0.327	0.362
	Lateral temporal	Female	0.322	0.005	0.312	0.333
	Lateral temporal	Male	0.306	0.005	0.296	0.317	1.000
Pi/ATP	Frontal	Female	0.490	0.031	0.430	0.551
	Frontal	Male	0.539	0.030	0.479	0.599
	Fusiform	Female	0.198	0.012	0.174	0.221
	Fusiform	Male	0.217	0.012	0.194	0.241
	Medial temporal	Female	6.928	0.218	6.500	7.358
	Medial temporal	Male	6.978	0.216	6.552	7.404
	PCC	Female	0.471	0.021	0.430	0.514
	PCC	Male	0.537	0.021	0.495	0.578
	Lateral temporal	Female	0.541	0.036	0.469	0.613
	Lateral temporal	Male	0.610	0.036	0.539	0.681	1.000
Pi/PCr	Frontal	Female	0.098	0.005	0.088	0.107
	Frontal	Male	0.091	0.005	0.081	0.100
	Fusiform	Female	0.179	0.009	0.162	0.196
	Fusiform	Male	0.186	0.008	0.169	0.202
	Medial temporal	Female	0.044	0.002	0.041	0.048
	Medial temporal	Male	0.044	0.002	0.040	0.048
	PCC	Female	0.085	0.005	0.075	0.096
	PCC	Male	0.087	0.005	0.077	0.097
	Lateral temporal	Female	0.058	0.003	0.052	0.064
	Lateral temporal	Male	0.060	0.003	0.054	0.066
PME/PDE	Frontal	Female	1.659	0.114	1.434	1.884	0.688
	Frontal	Male	1.903	0.113	1.679	2.126
	Fusiform	Female	0.919	0.046	0.829	1.009
	Fusiform	Male	0.956	0.045	0.866	1.045
	Medial temporal	Female	4.272	0.280	3.720	4.824
	Medial temporal	Male	4.699	0.278	4.151	5.247
	PCC	Female	1.684	0.204	1.281	2.087
	PCC	Male	2.071	0.203	1.671	2.471
	Lateral temporal	Female	3.127	0.240	2.653	3.600
	Lateral temporal	Male	3.280	0.238	2.810	3.750

Multi-variable adjusted, unstandardized mean (SE) and 95% confidence intervals (CI) by group (men, women). *Bonferroni corrected P values.
ATP, total adenosine triphosphate; PCC, posterior cingulate cortex and precuneus; PCr, phosphocreatine; Pi, inorganic phosphate; PDE, phosphodiesters; PME, phosphomonoesters.

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