Figure 4
Radiation-induced microRNA expression profiles in mouse liver tissue. Microarray analysis was performed for all samples, and a linear model was fit to each miRNA probe to assess differential expression of irradiated samples compared to controls. Criteria of |log2FC|> 1 and B-H p value < 0.05 relative to controls were used to determine significance and differential expression. (A) Heatmap displays expression patterns, represented by z-score, of all differentially expressed miRNAs across all doses and controls. (B) The number of down-regulated versus up-regulated miRNAs at each dose are shown in the table. (C) Venn diagram shows dose distribution and overlap of differentially expressed miRNAs across all doses. (D) Examples of significant linearly up- and down-regulated miRNAs are shown to display the dose response to radiation in liver tissue samples. Asterisk (*) indicates statistical significance.
