Figure 5 | Scientific Reports

Figure 5

From: Microarray analysis identifies coding and non-coding RNA markers of liver injury in whole body irradiated mice

Figure 5

Radiation-induced long non-coding RNA expression profiles in mouse liver tissue. (A) Heatmap displays expression patterns, of all differentially expressed lncRNAs across all doses and controls. A linear model was fit to each lncRNA probe to assess differential expression of irradiated compared to control samples using criteria of |log2FC|> 1 and B-H p value < 0.05. (B) The table shows the number of discrete down- versus up-regulated lncRNAs at each dose. (C) Venn diagram shows dose distribution and overlap of differentially expressed lncRNAs across all doses. (D) Examples of significant linearly up- and down-regulated lncRNAs are shown to display the dose response of lncRNAs to radiation in liver tissue samples. Asterisk (*) indicates statistical significance.

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