Figure 4
From: Mutation analysis of the WFS1 gene in a Chinese family with autosomal-dominant non-syndrome deafness
Mutation-induced structural changes in WFS1. (a) It shows superimposed view of wolframin protein in wild and mutant state. (b) Predicted structures depict the changes of mutant wolframin protein with the amino acid change S807R. Red and brown structures indicate differences between wild and mutant type. (c) A qualitative electrostatic representation of wolframin protein generated by PyMOL. Protein contact potentials can be represented by displaying virtual (false) red/blue charged smooth surfaces on wolframin protein. (d) A qualitative electrostatic representation of mutant S807R protein generated by PyMOL. The black circle indicates the position of amino acid 807. (e–f) The change of hydrogen bond between amino acids before and after mutation. The proteins are shown as cartoon. Amino acids at the mutated site 807 are highlighted in yellow and the interacting amino acids are highlighted in blue (red dotted line: the hydrogen bond).
