Figure 5 | Scientific Reports

Figure 5

From: Preclinical evaluation of pentagamavunone-1 as monotherapy and combination therapy for pancreatic cancer in multiple xenograft models

Figure 5

Establishment of a patient-derived xenograft mouse model. Resected specimens were cut into small pieces and directly implanted subcutaneously into the dorsal midline incisions made in nude mice with Matrigel matrix under anesthesia. (a) Photos of G0 and G4 in PDX-M. (b) Representative histological images of the primary tumor (left panels) and PDX-M of G4 (right panels) after HE staining. Low (upper panels) and high (lower panels) magnifications are shown. (c) Comparison of microscopic images between CDX-M and PDX-M. (d) Schema of the establishment of PDX-M and the experimental protocol to test anti-tumor effects.

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