Figure 2 | Scientific Reports

Figure 2

From: Genomic analysis of hypoxia inducible factor alpha in ray-finned fishes reveals missing Ohnologs and evidence of widespread positive selection

Figure 2

Synteny analysis of actinopterygian (a) HIF1A, (b) HIF2A, (c) HIF3A, and (d) HIF4A. The 10 flanking genes on either side of each HIFA paralog (gray arrows) are compared among spotted gar (Lepisosteus oculatus), Asian arowana (Scleropages formosus), zebrafish (Danio rerio), rainbow trout (Onchorhynchus mykiss), and southern platyfish (Xiphophorus maculatus). For each HIFA paralog, genes shared between spotted gar and more derived fishes are uniquely colored (see gene abbreviations in Supplemental Table S2). For HIF2A, genes shared among HIF2Ab but not present in HIF2Aa are shown in yellow. The relationships among fishes is from Hughes et al.37 and branch lengths do not indicate divergence times. The teleost-specific genome duplication is indicated by the blue diamonds, and putative losses of specific HIFA paralogs are shown by reds crosses.

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