Table 1 Nomenclature conventions and synonyms for the hypoxia inducible factor.

From: Genomic analysis of hypoxia inducible factor alpha in ray-finned fishes reveals missing Ohnologs and evidence of widespread positive selection

Example

Rule

HIF

hif

The Human Genome Consortium Gene Nomenclature Committee specifies uppercase Latin letters be used for gene symbols. The Zebrafish Nomenclature Conventions specify lowercase Latin letters for gene symbols

1,2,3,4

Paralogs that arose during two rounds of genome duplication at the base of vertebrate evolution are indicated by Arabic numbersa

A or B

a or b

The gene encoding the α and β subunits are distinguished by uppercase (humans) or lowercase (zebrafish) Latin lettersb

a or b

Paralogs that arose from the teleost-specific genome duplication are indicated by lowercase Latin letters

  1. The gene symbols for hypoxia inducible factors generally have four parts, corresponding to the gene name, the vertebrate-specific paralog, whether it encodes an α or β subunit, and the teleost-specific paralog (for fishes). This study follows the conventions for humans because it has been broadly applied to other vertebrates and invertebrates31.
  2. aThe hypoxia inducible factor 2 alpha subunit is also known as the endothelial PAS-domain protein, EPAS in humans and epas in zebrafish.
  3. bThe hypoxia inducible factor β subunit is also known as the aryl hydrocarbon receptor nuclear translocator, ARNT in humans and arnt in zebrafish.
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