Figure 8
From: The bile acid TUDCA reduces age-related hyperinsulinemia in mice
The bile acid TUDCA reduces age-related hyperinsulinemia and improves cognition in aged mice. TUDCA treatment for 20 days attenuated hyperinsulinemia and improved glucose homeostasis in 18-month-old mice, by enhancing liver IDE expression and insulin clearance. Furthermore, the improvement in glucose-insulin homeostasis in these mice was accompanied by a reduction in body weight, adiposity, and adipocyte hypertrophy, associated with reduced TG and CHOL levels in the liver. TUDCA-treated aged mice also displayed increased energy expenditure and ameliorated cognitive ability. In summary, these findings highlight TUDCA as an interesting target for the attenuation of age-related hyperinsulinemia and its deleterious effects on metabolism.
