Figure 2 | Scientific Reports

Figure 2

From: Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice

Figure 2

Decreased estrogenic response in cortical bone of S122A male mice. Three-month-old S122A and WT male mice were orx and treated with E2 pellet (16.7 ng/mouse·day) (WT, n = 9; S122A n = 11) or corresponding placebo (P) (WT, n = 10; S122A n = 11) pellet for four weeks. Cortical thickness (Ct.Th) (a) and trabecular bone volume per tissue volume (Trab. BV/TV) (b) of the tibia were analyzed by high resolution µCT. Representative images of cortical bone from high resolution µCT (c). Two-way ANOVA followed by Šidák´s multiple comparisons test. ***p < 0.001 vs Orx + P in respective genotype,##p < 0.01 Orx + E2 in S122A versus Orx + E2 in WT. All individual values are presented with mean (horizontal line) and SEM (vertical lines).

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