Table 1 Description of three-month-old male S122A (n = 8) and wild-type (WT, n = 11) littermates.

From: Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice

 

WT

S122A

ERα expression in cortical bone (AU)

3.3 ± 0.4

3.3 ± 0.4

Testosterone (pg/ml)

2771 ± 1821

2299 ± 1808

DHT (pg/ml)

61.9 ± 28.6

59.2 ± 36.4

E2 (pg/ml)

nd

nd

Total body aBMD (mg/cm2)

50.1 ± 0.6

51.0 ± 0.9

Tibia cortical thickness (μm)

193.1 ± 4.7

206.1 ± 6.4

Tibia trabecular BMD (mg/cm3)

249.5 ± 16.3

300.1 ± 25.3

Liver weight/bw (mg/g)

48.7 ± 0.9

46.1 ± 3.1

Thymus weight/bw (mg/g)

1.40 ± 0.04

1.29 ± 0.06

Testis weight/bw (mg/g)

7.6 ± 0.2

7.1 ± 0.2

Lean mass (g)

20.9 ± 0.6

21.9 ± 0.2

Total body fat mass (g)

4.4 ± 0.3

4.0 ±0.5

  1. ERα mRNA expression was measured by real-time PCR. Sex steroid levels were measured with GC–MS/MS. Body composition (total body aBMD, lean mass and total body fat mass) was measured by DXA, and bone parameters (trabecular BMD and cortical thickness) were analysed by pQCT. Values are given as mean ± SEM. Student's t-test, WT vs S122A mice. AU; arbitrary unit, nd; not detected, bw; body weight.
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