Figure 1

Representative brain imaging and NaF uptake intensity according to infarction lesion. Representative ¹⁸F-sodium fluoride (NaF) positron emission tomography and brain MR imaging demonstrated that NaF uptake is correlated with acute ischemic lesions from diffusion weighted images from four cerebral infarction patients (A–D, white arrows). The comparison of NaF uptake intensity between the diffusion-negative and diffusion-positive lesions revealed that both maximum (2.0 [0.60–4.2] versus 0.20 [0.10–0.40], p = 0.021, Mann–Whitney U test, E) and mean (1.4 [0.40–2.5] versus 0.30 [0.20–0.40], p = 0.018, Mann–Whitney U test, F) standardized uptake values were elevated among the infarction lesions with DWI ( +). DWI stands for diffusion-weighted image; FLAIR, fluid attenuated inversion recovery; SWI, susceptibility-weighted image; SUVmax, maximum standardized uptake value; SUVmean, mean standardized uptake value; *, statistically significant at p < 0.05.