Figure 8 | Scientific Reports

Figure 8

From: Improved β-cell function leads to improved glucose tolerance in a transgenic mouse expressing lipoprotein lipase in adipocytes

Figure 8

Glucose homeostasis and insulin secretion of control and AdipoQ-LpL mice. (A) Weight of the mice after switching to HFD (control n = 20; AdipoQ-LpL n = 21) or maintaining on chow (n = 12) starting at 8-weeks. (B) Glucose tolerance of control and AdipoQ-LPL mice after 16 weeks of HFD (control n = 20; AdipoQ-LpL n = 21). (C) Insulin tolerance of control and AdipoQ-LPL mice after 16 weeks of HFD (control n = 9; AdipoQ-LpL n = 9). Inset: analysis of area under the curve. (E,F) Plasma insulin levels after glucose injection of control and AdipoQ-LPL mice after chow or HFD for 16 weeks (control n = 11; AdipoQ-LPL n = 12; both cohorts 2 min glucose n = 6). Data were analyzed by RM 2 way ANOVA **P < 0.01; interaction P values for genotype are indicated in the figure.

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