Table 2 Enrichment of hallmark gene sets in adipose tissue.

From: Improved β-cell function leads to improved glucose tolerance in a transgenic mouse expressing lipoprotein lipase in adipocytes

Gene sets down in AdipoQ-LPL mice

Name

SIZE

ES

NES

NOM

P-val

FDR

q-val

HALLMARK_CHOLESTEROL_HOMEOSTASIS

72

− 0.65

− 1.78

0.002

0.127

HALLMARK_UNFOLDED_PROTEIN_RESPONSE

109

− 0.42

− 1.65

0.030

0.270

HALLMARK_MTORC1_SIGNALING

185

− 0.50

− 1.59

0.042

0.281

HALLMARK_TGF_BETA_SIGNALING

54

− 0.40

− 1.46

0.085

0.417

HALLMARK_UV_RESPONSE_UP

143

− 0.29

− 1.27

0.096

0.355

HALLMARK_MYC_TARGETS_V1

175

− 0.44

− 1.58

0.100

0.235

HALLMARK_APICAL_JUNCTION

198

− 0.33

− 1.29

0.101

0.431

HALLMARK_HYPOXIA

191

− 0.32

− 1.28

0.105

0.385

HALLMARK_MYOGENESIS

195

− 0.38

− 1.28

0.106

0.413

Gene sets up in AdipoQ-LPL mice

HALLMARK_PANCREAS_BETA_CELLS

37

0.58

1.69

0.008

0.137

HALLMARK_COAGULATION

131

0.44

1.39

0.061

0.578

  1. The microarray data for adipose tissue gene expression was analyzed by GSEA to evaluate hallmark gene sets downregulated or upregulated in AdipoQ-LPL mice. The name of the pathway, number of genes (SIZE), Enrichment and normalized enrichment scores, Nominal P values and false discovery rate q-values generated by GSEA are indicated.
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