Figure 6
From: Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids
Uniform Manifold Approximation and Projection (UMAP) visualization of cell clusters identified during scRNA-seq analysis of mouse whole brain tissue and SCFA receptors and transporters expression. (Panel A) identifies each cell type by name and color. (Panel B) illustrates the expression of microglia markers (C1qa, C1qb, C1qc, Ctss, and Tmem 119) used to identify microglial cells. (Panels C and D) illustrate the expression of SCFA receptors, Ffar2, Ffar3, and Olfr78, and transporters, Mct1 (Slc16a1) and Mct4 (Slc16a3), respectively. Microglia lack the expression of all receptors but express both transporters.
