Table 1 Recipient and donor demographic data and baseline characteristics for SPK and SPLK groups in the study.

From: Comparison of long-term outcomes in simultaneous pancreas-kidney transplant versus simultaneous deceased donor pancreas and living donor kidney transplant

Variables

Overall (n = 195)

SPK (n = 149)

SPLK (n = 46)

P-value*

Recipient characteristics

Age, years

41.3 ± 8.4

41.6 ± 8.5

40.2 ± 8.0

0.339

Female sex

97 (49.7)

77 (52.0)

20 (43.5)

0.311

Body mass index, kg/m2

21.2 ± 2.9

21.3 ± 2.7

30.9 ± 3.6

0.368

Onset of DM, years

20.9 ± 8.3

20.4 ± 8.1

22.7 ± 8.8

0.1

Duration of DM, years

20.2 ± 6.7

21.1 ± 6.0

17.8 ± 7.9

0.004

Insulin amount in use, IU/day

29.4 ± 20.9

28.2 ± 22.1

33.2 ± 16.0

0.157

HbA1c, %

7.55 ± 1.53

7.57 ± 1.59

7.49 ± 1.30

0.776

C-peptide, ng/mL

3.15 ± 4.42

3.53 ± 4.72

1.98 ± 3.10

0.012

Anti-GAD antibody, U/mL

1.86 ± 8.53

1.63 ± 7.79

2.6 ± 10.7

0.288

Bladder drainage

36 (18.4)

0 (0)

36 (78.3)

 < 0.001

Presensitized patients (PRA > 20%)

52 (26.8)

44 (29.7)

8 (17.4)

0.099

HLA mismatch, n

3.56 ± 1.66

3.94 ± 1.31

3.40 ± 1.78

0.027

 Kidney

–

–

2.76 ± 1.93

 

 Pancreas

–

–

4.07 ± 1.31

 

 Donor-Donor**

–

–

4.35 ± 1.32

 

Number of readmissions, n

3.91 ± 4.57

3.23 ± 3.69

6.09 ± 6.19

0.034

Operating time, minutes

445.8 ± 76.2

443.2 ± 75.4

454.3 ± 78.7

0.683

Hospital days, days

31.4 ± 17.6

31.8 ± 19.1

30.0 ± 11.3

0.213

Waiting time, months

43.9 ± 33.1

54.9 ± 29.6

8.4 ± 12.4

 < 0.001

Donor characteristics

Age, years

30.1 ± 11.5

   

 Pancreas

 

31.7 ± 11.9

24.9 ± 8.2

 < 0.001

 Kidney

 

31.7 ± 11.9

44.0 ± 11.0

 

Female sex

63 (32.5)

   

 Pancreas

 

50 (33.8)

13 (28.3)

0.119

 Kidney

 

50 (33.8)

27 (58.7)

 

Body mass index, kg/m2

21.8 ± 3.4

   

 Pancreas

 

22.0 ± 3.4

21.2 ± 3.4

0.722

 Kidney

 

22.0 ± 3.4

24.4 ± 2.8

 

Cold ischemic time, minutes

    

 Pancreas

422.3 ± 131.7

412.1 ± 132.3

455.6 ± 125.3

0.052

 Kidney

277.8 ± 156.8

331.7 ± 130.0

93.7 ± 83.3

 < 0.001

Cause of death, CVA

38 (19.6)

33 (22.3)

5 (10.9)

0.088

Pancreas graft weight, mg

184.6 ± 43.9

182.8 ± 44.5

190.6 ± 41.8

0.302

Kidney graft weight, mg

184.9 ± 43.2

185.8 ± 45.1

181.7 ± 36.7

0.49

Induction regimen

   

–

Antithymocyte globulin

194 (100)

148 (100)

46 (100)

–

Basiliximab

0 (0)

0 (0)

0 (0)

 

Calcineurin inhibitor

   

0.428

Tacrolimus

192 (99.0)

146 (99.0)

46 (100)

 

Cyclosporine

2 (1.0)

2 (1.0)

0 (0)

 
  1. SPK simultaneous pancreas-kidney transplant, SPLK simultaneous deceased donor pancreas and living donor kidney transplant, DM diabetes mellitus, HLA human leukocyte antigen, CVA cerebrovascular accident.
  2. *SPK vs. SPLK/Data are mean ± standard deviation or n (%).
  3. **Counted HLA antigens present on living kidney donor but not on the deceased pancreas donor.
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