Table 1 Characteristics of recruited AD and PV patients and age matched controls for the study of skin tissue samples.
Profiling analysis | Validation analysis | |||||||
|---|---|---|---|---|---|---|---|---|
All subjects | AD | PV | Controls | All subjects | AD | PV | Controls | |
N = 31 | N = 11 | N = 11 | N = 9 | N = 33 | N = 12 | N = 12 | N = 9 | |
Age, yearsA | 39.32 ± 13.92 | 36.27 ± 18.10 | 43.82 ± 12.53 | 37.56 ± 8.79 | 40.52 ± 14.44 | 37.50 ± 17.77 | 45.75 ± 13.69 | 37.56 ± 8.79 |
Sex, female, n (female %)B | 14 (45.2%) | 7 (63.6%) | 3 (27.3%) | 4 (44.4%) | 14 (45.2%) | 7 (58.3%) | 3 (25.0%) | 4 (44.4%) |
Age of onset, yearsA | ˂ 40 | ˂ 40 | ||||||
Severity of AD | ||||||||
moderate (IGA = 3), n (%)B | 6 (54.5%) | 7 (58.3%) | ||||||
severe (IGA = 4), n (%)B | 5 (45.5%) | 5 (41.7%) | ||||||
Severity of PV, PASI scoreA | 10.23 ± 4.53 | 11.01 ± 5.09 | ||||||
Affected joints, n (%) | 7 (63.6%) | 8 (66.7%) | ||||||
Affected nails, n (%) | 5 (45.5%) | 6 (50.0%) | ||||||
Affected head, n (%) | 6 (54.5%) | 7 (58.3%) | ||||||
Asthma, yes n (yes %)B | 1 (3.2%) | 1 (9.1%) # | 0 (0%) | 0 (0%) | 1 (3.0%) | 1 (8.3%) # | 0 (0%) | 0 (0%) |
hsa-miR-31-5p relative signal, log2 or 2-ΔCt | 4.83 ± 3.12 | 6.20 ± 0.92^ | 7.25 ± 0.63*^ | 0.19 ± 0.13 | 32.26 ± 28.10 | 21.19 ± 19.89 | 66.35 ± 38.46*^ | 1.58 ± 1.25 |
hsa-miR-378a-3p relative signal, log2 or 2-Δ-Ct | 7.01 ± 0.69 | 7.29 ± 0.52^ | 7.40 ± 0.37^ | 6.18 ± 0.41 | 4.54 ± 2.92 | 4.97 ± 2.67^ | 6.63 ± 1.73^ | 1.16 ± 0.72 |
hsa-miR-28-5p relative signal, log2 or 2-Δ-Ct | 2.88 ± 1.95 | 3.71 ± 1.79^ | 3.73 ± 1.47^ | 0.83 ± 0.71 | 3.53 ± 2.21 | 4.95 ± 2.10^ | 3.91 ± 1.59^ | 1.15 ± 0.68 |
hsa-miR-203a relative signal, log2 or 2-Δ-Ct | 8.75 ± 0.67 | 8.96 ± 0.47^ | 9.21 ± 0.27^ | 7.92 ± 0.46 | 1.57 ± 0.90 | 1.27 ± 0.39* | 2.27 ± 1.14^ | 1.03 ± 0.23 |
