Figure 2

Correlates of fast ripple (FR) resection ratios and relative rates with outcome. (A) Violin plots of FR frequency distribution stratified by the resected electrodes and post-operative seizure outcome Engel (E) class. Fast ripples were increased in frequency in the resection margins of E1 patients (GLMM, p < 1e-10), but decreased in frequency in the resection margins of E2-4 patients (GLMM, p < 1e-8)(B) Box plot of the FR resection ratio (RR) stratified by Engel class for FR > 350 Hz (top, p > 0.05 spearman rank correlation) and all FR irrespective of frequency (bottom, p > 0.05 spearman). (C) Receiver operating characteristic (ROC) curves of seizure-free classification (E1,green) and improvement classification (E < 4,black) by FR > 350 Hz rates (top) and all FR rates (bottom) including the area under the ROC curve (AUC). The RR cutoff was 0.192 and 0.366 for FR > 350 Hz and all FR for seizure-free classification, respectively. The RR cutoff was 0.192 and 0.272 for FR > 350 Hz and all FR for improvement classification, respectively.