Table 1 Metrics of the confusion matrices derived from each of the fast ripple (FR) resection measures at Youden’s J of the respective receiver operating charecteristic (ROC) curves for predicting post-operative seizure free outcome (top) and improvement in seizures (bottom). Brackets indicate the 95% confidence interval. For the patients without FR mutual information (MI) networks, (i.e., indeterminate) confusion matrices values were imputed appropriately (see supplementary methods).

FR 350 Hz RR

1 [0.85 1]

0.385 [0.08 0.45]

0.529 [0.45 0.86]

1 [0.85 1]

0.636 [0.55 0.92]

FR all RR

0.7 [0.61 0.95]

0.538 [0.34 0.77]

0.538 [0.2 0.61]

0.7 [0.47 0.87]

0.609 [0.61 0.95]

FR rate-distance

1 [0.85 1]

0.615 [0.31 0.73]

0.667 [0.47 0.87]

1 [0.85 1]

0.783 [0.66 0.97]

FR MI Path length

0.9 [0.52 0.9]

0.462 [0.2 0.61]

0.563 [0.31 0.73]

0.857 [0.66 0.97]

0.652 [0.47 0.87]

FR MI Clust. Coeff

0.667 [0.45 0.86]

0.692 [0.5 0.89]

0.6 [0.45 0.86]

0.75 [0.55 0.92]

0.682 [0.32 0.76]

FR MI Local Eff

0.556 [0.22 0.66]

0.667 [0.34 0.78]

0.556 [0.53 0.92]

0.667 [0.38 0.82]

0.619 [0.43 0.85]

FR MI Local Eff. UR

0.8 [0.52 0.9]

0.462 [0.31 0.73]

0.533 [0.34 0.77]

0.75 [0.66 0.97]

0.609 [0.43 0.84]

FR 350 Hz RR

1 [0.85 1]

0.556 [0.43 0.84]

0.778 [0.52 0.9]

1 [0.85 1]

0.826 [0.61 0.95]

FR all RR

0.857 [0.61 0.95]

0.556 [0.47 0.87]

0.75 [0.72 0.99]

0.714 [0.52 0.9]

0.739 [0.52 0.9]

FR rate-distance

0.857 [0.66 0.97]

0.667 [0.52 0.90]

0.80 [0.61 0.95]

0.75 [0.39 0.80]

0.783 [0.52 0.90]

FR MI Path length

0.833 [0.61 0.95]

0.636 [0.34 0.77]

0.714 [0.39 0.8]

0.778 [0.47 0.87]

0.739 [0.56 0.93]

FR MI Clust. Coeff

0.636 [0.45 0.86]

0.636 [0.5 0.89]

0.636 [0.45 0.86]

0.636 [0.28 0.72]

0.636 [0.45 0.86]

FR MI Local Eff

0.4 [0.22 0.66]

0.727 [0.48 0.89]

0.571 [0.3 0.74]

0.571 [0.43 0.85]

0.571 [0.43 0.85]

FR MI Local Eff. UR

0.75 [0.56 0.93]

0.636 [0.31 0.73]

0.692 [0.47 0.87]

0.7 [0.47 0.87]

0.696 [0.52 0.9]