Table 2 Fifteen loci were found to be associated with delta age with at least suggestive significance (\(p\le 1 \times 10^{-6}\)).
From: Deep learning-derived cardiovascular age shares a genetic basis with other cardiac phenotypes
Chr. | Gene | rsID | Pos. | Ref. | Alt. | AF | Effect size | \(P\)-value |
|---|---|---|---|---|---|---|---|---|
14 | SIPA1L1 | rs35866366 | 71849185 | A | G | 0.25 | 0.52 (0.39, 0.64) | 1.1e-15 |
6 | VGLL2 | rs6901720 | 117510203 | G | T | 0.47 | 0.43 (0.32, 0.54) | 2.8e-14 |
4 | CAMK2D | rs35430511 | 114387138 | T | C | 0.26 | 0.49 (0.36, 0.61) | 3.1e-14 |
8 | DEFB136 | rs4240678 | 11802426 | C | T | 0.40 | 0.47 (0.32, 0.62) | 4.9e-10 |
2 | TTN | rs11902709 | 179608207 | C | T | 0.05 | 0.78 (0.52, 1.03) | 3.0e-09 |
3 | SCN5A | rs6773331 | 38684397 | A | T | 0.98 | 1.24 (0.82, 1.66) | 9.1e-09 |
3 | SCN10A | rs6801957 | 38767315 | T | C | 0.59 | −0.32 (−0.43, −0.21) | 2.1e-08 |
5 | PKD2L2 | rs10076361 | 137252940 | G | A | 0.18 | 0.41 (0.27, 0.55) | 2.3e-08 |
8 | EXT1 | rs57237854 | 118860126 | ATCTTG | A | 0.18 | 0.40 (0.25, 0.54) | 5.3e-08 |
10 | AGAP5 | rs147790633 | 75447582 | T | C | 0.14 | −0.43 (−0.59, −0.27) | 8.7e-08 |
10 | CTNNA3 | rs72799115 | 68008504 | G | A | 0.21 | 0.35 (0.22, 0.49) | 2.0e-07 |
12 | TBX3 | rs1896329 | 115357432 | C | T | 0.69 | −0.31 (−0.42, −0.19) | 3.9e-07 |
2 | SPTBN1 | rs1802889 | 54756740 | C | T | 0.68 | −0.30 (−0.42, −0.19) | 4.4e-07 |
12 | SOX5 | rs12826024 | 24776799 | G | A | 0.15 | −0.39 (−0.54, −0.24) | 6.1e-07 |
16 | CHD9 | rs75778953 | 52906677 | C | T | 0.01 | −1.25 (−1.74, −0.76) | 6.2e-07 |
