Figure 3
Anti-EBOV GP antibody epitope mapping based on SP-IRIS data. Top image shows the epitopes for protective mAbs on the EBOV GP structure. Reproduced with permission from32. The bottom table shows the grouping of mAbs against Ebola virus GP based on their signal levels on SP-IRIS. Group 1 antibodies show the highest level of binding on SP-IRIS with binding sites either on the mucin-like domain or glycan cap, the most accessible areas on the GP for binding. Group 2 antibodies have intermediate binding levels on SP-IRIS and they bind to the GP1/GP2 interface of the GP in the base domain. Group 3 antibodies show little or no binding on SP-IRIS. These antibodies bind either to the base domain with a steeper angle than the Group 2 antibodies or MPER region which is the region of the GP that is the closest to the viral membrane.
