Table 1 Summary of main pharmacokinetic parameters of two formulations of Omeprazole and sodium bicarbonate powder.

From: Pharmacokinetics and bioequivalence evaluation of omeprazole and sodium bicarbonate dry suspensions in healthy Chinese volunteers

Parameter

Arithmetic mean ± SD (%CV) (N = 40)

p

Test preparation

Reference preparation

Cmax (ng mL−1)

981.50 ± 431.72 (43.99)

1010.35 ± 430.97 (42.66)

0.77

Tmax (h)

0.25 (0.17,0.75)

0.25 (0.08,1.00)

0.32

AUC0–t (ng h mL−1)

1530.61 ± 1584.30 (103.51)

1553.81 ± 1618.30 (104.15)

0.95

AUC0–∞ (ng h mL−1)

1572.21 ± 1642.10 (104.45)

1594.10 ± 1676.30 (105.16)

0.95

T1/2 (h)

1.15 ± 0.71 (61.77)

1.15 ± 0.68 (59.05)

0.99

λz (h−1)

0.774 ± 0.308 (39.84)

0.759 ± 0.290 (38.19)

0.82

CL (L h kg−1)

27.96 ± 23.69 (84.75)

27.03 ± 20.19 (74.74)

0.85

Vd (L kg−1)

27.42 ± 13.38 (48.8)

25.02 ± 9.43 (37.69)

0.36

  1. Cmax maximum blood concentration, Tmax time to maximum blood concentration, AUC0–t Area under curve from time 0 (baseline) to time t, AUC0–∞ Area under curve from zero to infinity, T1/2 elimination half-life, λz apparent end elimination rate constant, CL plasma clearance, Vd, apparent volume of distribution. Data was presented in mean ± standard deviation.
  2. p > 0.05, No significant.
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