Table 3 The PK of test and reference preparation about CYP2C19 phenotypes.

CYP2C19 gene polymorphisms	AUC_0–t (ng h mL⁻¹)		AUC_0–∞		C_max(ng mL⁻¹)		T_1/2 (h)		T_max (h)		λz (h⁻¹)		CL (L h kg⁻¹)		V_d (L kg⁻¹)
CYP2C19 gene polymorphisms	T	R	T	R	T	R	T	R	T	R	T	R	T	R	T	R
EM (N = 12)	552.90 ± 391.42	591.09 ± 401.03	563.59 ± 378.58	600.82 ± 387.43	633.25 ± 295.94	690.50 ± 338.19	0.74 ± 0.19	0.78 ± 0.17	0.25 (0.17, 0.75)	0.25 (0.17, 0.5)	0.99 ± 0.2	0.92 ± 0.19	50.95 ± 28.09	45.23 ± 23.32	35.03 ± 18.45	24.68 ± 11.92
IM (N = 24)	1520.14 ± 1437.90	1475.31 ± 1356.51	1558.7 ± 1495.48	1508.26 ± 1402.83	1044.21 ± 320.07	1060.33 ± 303.17	1.13 ± 0.65	1.11 ± 0.63	0.25 (0.17, 0.5)	0.25 (0.08, 0.5)	0.75 ± 0.27	0.76 ± 0.26	20.4 ± 11.91	21.72 ± 11.78	25.55 ± 9.06	26.78 ± 7.98
PM (N = 4)	4526.56 ± 651.59	4913.02 ± 738.77	4679.13 ± 627.44	5089.02 ± 742.13	1650.00 ± 451.66	1670.00 ± 530.28	2.48 ± 0.24	2.46 ± 0.16	0.3 (0.25 0.5)	0.29 (0.17, 1)	0.28 ± 0.03	0.28 ± 0.18	4.32 ± 0.54	4.28 ± 0.25	15.79 ± 3.32	15.79 ± 0.74
p (EM/IM)	< 0.05	< 0.05	< 0.05	< 0.05	< 0.001	0.002	0.049	0.08	0.96	0.67	0.01	0.06	0.04	0.5	< 0.001	< 0.001
p (EM/PM)	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.48	0.24	< 0.001	< 0.001	0.06	0.15	0.005	0.004
p (IM/PM/)	< 0.001	< 0.001	< 0.001	< 0.001	0.002	0.002	< 0.001	< 0.001	0.41	0.14	0.002	0.001	0.045	0.009	0.01	0.007

C_max maximum blood concentration, T_max time to maximum blood concentration, AUC_0–t Area under curve from time 0 (baseline) to time t, AUC_0–∞ Area under curve from zero to infinity, T_1/2 elimination half-life, λz apparent end elimination rate constant, CL plasma clearance, V_d, apparent volume of distribution. Data was presented in mean ± standard deviation. p > 0.05, not significant.

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