Figure 4 | Scientific Reports

Figure 4

From: Antiplasmodial activity, structure–activity relationship and studies on the action of novel benzimidazole derivatives

Figure 4The alternative text for this image may have been generated using AI.

Effect of selected benzimidazole derivatives on ROS production. Five potent compounds were incubated with P. falciparum-infected cultures and the production of reactive oxygen species was measured through fluorometry at 0.5, 6 and 9 h after their addition at 1 µM. As positive control, a sample containing hydrogen peroxide at 200 μM was added. Samples were measured in triplicates. One-way ANOVA with Turkey´s comparison was used to measure significance with respect to the untreated control at each different time point. n = 2. (a) BZ 1, (b) BZ 5, (c) BZ 16, (d) BZ 26 and (e) BZ 33. *p < 0.05, **p < 0.01, ***p < 0.005.

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