Table 2 Growth inhibition, IC50, cytotoxicity and selectivity index of 2-amidobenzimidazole derivatives in 7G8 P. falciparum parasites.

From: Antiplasmodial activity, structure–activity relationship and studies on the action of novel benzimidazole derivatives

Nº

R1

R2

7G8 Pf IC50 (µM)

Cytotoxicitya CC50 (μM)

SI

1

5-CH3

pyridin-2-yl

0.95

14.8

15.6

12

5-Cl

pyridin-2-yl

3.60

15.4

4.2

16

5-Cl

5-methylpyridin-2-yl

2.60

7.2

2.7

CQ*

  

0.23

nc

nc

  1. acytotoxicity tested in Vero cells.
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