Figure 4 | Scientific Reports

Figure 4

From: Protein KIC5 is a novel regulator of artemisinin stress response in the malaria parasite Plasmodium falciparum

Figure 4

Clustering of dysregulation genes across the KIC5 transcriptome. Cluster heatmap of KIC5 mutant log2-fold change (log2FC) values. Bioinformatic analysis to determine optimal clustering identified 6 gene clusters with similar differential expression patterns in the KIC5 mutant clone compared to the isogenic wild-type NF54 clone (Supplementary Fig. 7, Supplementary Table S11). The location of protein KIC5 and K13 in the heatmap are indicated with arrows. Heatmap displayed as Expression Z-score of log2-fold change (KIC5 mutant/NF54) values. Top GO biological processes of each cluster are shown in the corresponding tables, analyzed via PlasmoDB gene ontology enrichment tool (Supplementary Table S12). Significant p-value < 0.05.

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