Figure 5

Behavioral tests for MCAO mice with or without OP9-pre-conditioned UCB administration. Mice were randomly assigned to three groups: the UCB + OP9 group (n = 11), the control group (n = 11), and the sham surgery group (n = 12). The open field test (a), the Y-maze task (b), the passive avoidance learning test (c), the wire hang test (d), and the forced swimming test were conducted 1.5 month after the surgery. Before multiple comparisons, one-way analysis of variance for the Y-maze task and a two-way repeated measured ANOVA for data arising from repeated measures (i.e., the open field test, passive avoidance learning task, wire hang test, and the forced swimming test) were used. A; p < 0.05, Dunnett’s test for differences between-subject. *p < 0.05, **p < 0.01, ***p < 0.001, Dunnett’s test in comparison of the sham surgery group with the control group (i.e., the MCAO induced group). #p < 0.05, ##p < 0.01, Dunnett’s test in comparison of the OP9 + UCB group (i.e., the MCAO induced and OP9-pre-conditioned UCB-administered group) with the control group. ^†p < 0.05, ^††p < 0.01, Dunnett’s test compared with the conditioning trials of each group.