Figure 3

Intestinal permeability measured by urinary excretion of sugar substitutes following three consecutive nights of adequate sleep (AS) or sleep restriction (SR). Five-hour urinary excretion of (a) lactulose and (b) mannitol expressed as percent of dose administered. (c) Lactulose:mannitol ratio. (a–c) Mixed model ANOVA; all data log10-transformed for analysis. Median and interquartile range shown. n = 17.