Table 2 Patient characteristics and Selected variables in the SEERa by multivariate Cox’s regression analysis.

From: Development of nomogram and discussion of radiotherapy effect for osteosarcoma survival

Variables

N

Multivariate analysis

HRb

95% CI

p valuec

Age

0–14

910

Reference

  

15–19

677

1.203

1.013–1.428

p < 0.05

20–39

799

1.202

1.010–1.431

p < 0.05

40–59

608

2.131

1.794–2.532

p < 0.05

≥ 60

572

3.509

2.926–4.210

p < 0.05

Sex

Male

1932

Reference

  

Female

1634

0.889

0.802–0.985

p < 0.05

Primary site

Upper limb

392

Reference

  

Lower limb

2006

0.809

0.682–0.959

p < 0.05

Other sites

1168

1.113

0.928–1.334

p < 0.05

Surgery

None

461

Reference

  

Yes

3105

0.364

0.320–0.414

p < 0.05

Histologic type

Osteosarcoma

2377

Reference

  

Chondroblastic

531

1.058

0.917–1.219

 

Other type

658

0.799

0.686–0.931

p < 0.05

Grade

Low grade (G1 + G2)

446

Reference

  

G3

1060

2.584

2.058–3.244

p < 0.05

G4

2060

2.683

2.153–3.342

p < 0.05

Radiation

None

384

Reference

  

Yes

3182

1.311

1.135–1.515

p < 0.05

Chemotherapy

None

796

Reference

  

Yes

2770

0.886

0.775–1.014

0.07

Tumor size

≤ 8 cm

1303

Reference

  

> 8 cm

1434

1.551

1.375–1.515

p < 0.05

Unknown

829

1.413

1.227–1.627

p < 0.05

  1. aSurveillance, Epidemiology, and End Results.
  2. bHazard ratio.
  3. cp < 0.05 mains significantly different.
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