Figure 5
From: Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2
Motions of residue L480 in the HREMD simulations of monomeric mGBP2. (a) Reference conformation of the mGBP2 is shown for the calculation of the coordinate distances difference (\(\Delta x\), \(\Delta y\), \(\Delta z\)) of L480. (b) The evolution of these distances (\(\Delta x\): green, \(\Delta y\): red, \(\Delta z\): blue) is shown for \(\hbox {mGBP2}_{\mathrm{apo}}\) (top), \(\hbox {mGBP2}_{\mathrm{GTP}}\) (middle), and \(\hbox {mGBP2}_{\mathrm{holo}}\) (bottom). The solid lines show the running average and the shades illustrate the raw data. Furthermore, the zero line is shown in black, whereas the vertical orange line indicates the frame with the maximal distance of the L480 residue between reference structure and 200 ns HREMD simulations.
