Table 2 Summary of the molecular effects of nsPEF on pancreatic cancer cells (+ slight effect, ++ moderate effect, +++ high effect).
EPP85-181RDB | EPP85-181RNOV | EPP85-181P | |
|---|---|---|---|
Permeabilization | No | Yes | No |
Membrane response | Release of microvesicles | No morphological change | Cell shrinkage |
Actin response | Lack in the periphery | No visible effect | Reorganization |
CD91 and CD243 colocalization | Most variable | Colocalized | Colocalized |
Effect of nsPEF on chemotherapy resistance | Yes | No | No |
Long lasting attenuation of cancer growth | No | Yes | No |
Induction of cells adherence | + | ++ | + |
Loss of cadherin | +++ | +++ | ++ |
