Figure 4 | Scientific Reports

Figure 4

From: Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK–SIRT1–PGC1a energy metabolism pathway

Figure 4

CR induces apoptosis in the peri-infarct myocardium of aged mice. (A) Representative images of apoptosis (in green) evaluated with TUNEL staining for. Nuclei were depicted by DAPI in blue. (B) Quantification of TUNEL positive (a) apoptotic cardiomyocyte nuclei in frozen sections from peri-infarct region after 24 h reperfusion. Data were from 6 randomly selected images. The group: y-AL young ad libitum group, a-AL aged ad libitum group, a-CR aged caloric restriction group. *P < 0.05 vs y-AL; #P < 0.05 vs a-AL; ‡P < 0.05 vs sham operation.

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