Figure 2
From: Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans
Distribution of MMA values in plasma and urine at V3 and V7 in individuals with medium MMA levels in dependence of treatment. MMA values for plasma (nmol/L, left, A and B) and urine samples (µmol/mmol creatine, right, C and D) for placebo (green) and linagliptin (blue) at V3 (top, A and C), and V7 (bottom, B and D). The number of samples in each group is shown at the top right. Statistically significant differences between placebo and linagliptin are indicated (Welch t-test). Data is shown as a box-and-whisker plot and the corresponding kernel density estimation. The data shows a shift of MMA values at V7 to the right (towards higher MMA values) in the Placebo group. The shift is also depicted in median and mean values shown in Tables 5 and 6, respectively. MMA, methylmalonic acid; n.s., not significant; V3, baseline; V7, end of study.
