Table 3 Disease activity scores of patients with AS assessed in all three phases (n = 126).

From: Investigation of changes in ankylosing spondylitis disease activity through 2021 COVID-19 wave in Taiwan by using electronic medical record management system

 

Pre-COVID-19-wave phase (A)

COVID-19-wave phase (B)

Post-COVID-19-wave phase (C)

(B)-(A)

p value#

(C)-(B)

p value#

(C)-(A)

p value#

ESR (mm/h)

6.0 (3.0, 12.0)

6.0 (3.0, 12.0)

8.0 (4.0, 15.0)

0.0 (− 1.0, 2.0)

0.284

1.0 (− 1.0, 4.0)

0.003

1.0 (− 1.0, 5.0)

 < 0.001

CRP (mg/dL)

0.2 (0.1, 0.4)

0.2 (0.1, 0.5)

0.2 (0.1, 0.5)

0.01 (− 0.02, 0.2)

0.001

0.0 (− 0.1, 0.1)

0.272

0.02 (− 0.03, 0.1)

 < 0.001

ASDAS-ESR

1.3 (0.9, 1.9)

1.2 (0.9, 1.8)

1.4 (1.0, 1.9)

0.0 (− 0.2, 0.2)

0.839

0.1 (− 0.2, 0.3)

0.032

0.1 (− 0.1, 0.4)

0.022

ASDAS-CRP

1.2 (0.8, 1.6)

1.2 (0.7, 1.8)

1.3 (0.8, 1.8)

0.1 (− 0.2, 0.3)

0.051

0.0 (− 0.2, 0.3)

0.734

0.1 (− 0.2, 0.4)

0.016

BASDAI

1.4 (0.6, 2.6)

1.6 (0.6, 2.8)

1.5 (0.6, 2.6)

0.0 (− 0.3, 0.4)

0.163

0.0 (− 0.6, 0.2)

0.024

0.0 (− 0.4, 0.4)

0.958

Back pain

1.0 (0.0, 3.0)

1.0 (1.0, 3.0)

1.0 (0.0, 3.0)

0.0 (− 1.0, 1.0)

0.375

0.0 (− 1.0, 0.0)

0.072

0.0 (0.0, 0.0)

0.324

Peripheral pain/swelling

1.0 (0.0, 2.0)

1.0 (0.0, 2.0)

1.0 (0.0, 3.0)

0.0 (0.0, 1.0)

0.362

0.0 (− 1.0, 1.0)

0.712

0.0 (0.0, 1.0)

0.168

Duration of morning stiffness

1.0 (0.0, 2.0)

1.0 (0.0, 2.0)

1.0 (0.0, 2.0)

0.0 (0.0, 0.0)

0.830

0.0 (0.0, 0.0)

0.676

0.0 (0.0, 0.0)

0.469

Patient global assessment

1.0 (0.0, 3.0)

1.0 (0.0, 2.0)

2.0 (0.0, 3.0)

0.0 (− 1.0, 1.0)

0.767

0.0 (0.0, 1.0)

0.561

0.0 (0.0, 1.0)

0.394

Fatigue

2.0 (1.0, 4.0)

2.0 (1.0, 4.0)

2.0 (1.0, 3.0)

0.0 (− 1.0, 1.0)

0.369

0.0 (− 1.0, 0.0)

0.016

0.0 (− 1.0, 1.0)

0.204

Areas of localized tenderness

1.0 (0.0, 2.0)

1.0 (0.0, 3.0)

1.0 (0.0, 3.0)

0.0 (− 1.0, 1.0)

0.336

0.0 (− 1.0, 1.0)

0.202

0.0 (− 1.0, 1.0)

0.713

Degree of morning stiffness

1.0 (0.0, 3.0)

1.0 (0.0, 2.0)

1.0 (0.0, 3.0)

0.0 (0.0, 0.0)

0.189

0.0 (0.0, 0.0)

0.559

0.0 (0.0, 1.0)

0.680

  1. All patients with AS were assessed using the EMRMS between Feb 7 and Oct 16, 2021.
  2. Pre-COVID-19-wave phase: 6th–17th week of 2021 (February 7–May 1, 2021).
  3. COVID-19-wave phase: 18th–29th week of 2021 (May 2–July 24, 2021).
  4. Post-COVID-19-wave phase: 30th–41st week of 2021 (July 25–October 16, 2021).
  5. *The weekly calculations are based on WHO’s year-week comparison table, where each week includes all 7 days and the first week of each year does not necessarily include January 1.
  6. #Kolmogorov–Smirnov p value < 0.05, Wilcoxon Signed Rank Test is used.
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