Figure 2 | Scientific Reports

Figure 2

From: PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia

Figure 2

Illustration of the tyrosine receptor pathway activated in canine mammary tumors. Membranous tyrosine kinase receptors such as the HER2 receptor activated the downstream KRAS and PIK3CA pathway leading to downstream cellular proliferations and cell survival. Canine mammary tumors show evidence for activation of PIK3CA and KRAS as well as inactivation of PTEN leading to increased activity of this pathway. Illustration modified from Kim et al. 202024.

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