Table 1 Renal function test of experimental mice treated with high doses of 5B2T.

From: In silico and in vivo hepatoprotective activity of the synthesized 5-benzylidene-2-thiohydantoin against diethylnitrosamine-induced liver injury in a rat model

Groups

Blood urea (mg/dL)

BUN (mg/dL)

Creatinine (mg/dL)

Uric acid (mg/dL)

Serum protein (mg/dL)

Serum albumin (mg/dL)

Male mice

 Vehicle

20.1 ± 0.8

24.7 ± 0.01

1.2 ± 1.8

6.5 ± 0.4

6.0 ± 2.3

3.5 ± 0.3

 2 g/kg 5B2T

21.5 ± 1.6

24.3 ± 0.07

1.3 ± 1.1

6.4 ± 0.2

6.1 ± 2.1

3.6 ± 0.2

 5 g/kg 5B2T

20.2 ± 0.8

23.8 ± 0.08

1.2 ± 1.6

6.3 ± 0.5

6.5 ± 0.9

3.5 ± 1.2

Female mice

 Vehicle

20.0 ± 0.1

24.1 ± 0.1

1.1 ± 0.6

6.2 ± 1.3

6.3 ± 0.1

3.4 ± 2.7

 2 g/kg 5B2T

21.0 ± 0.3

24.8 ± 2.1

1.1 ± 0.7

6.4 ± 0.1

6.1 ± 0.1

3.5 ± 1.3

 5 /kg 5B2T

22.2 ± 0.7

24.2 ± 2.2

1.1 ± 0.3

6.5 ± 0.5

6.1 ± 0.1

3.3 ± 0.9

  1. Values expressed as mean ± S.E.M. There are no significant differences between groups. Significant value at p < 0.05.
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